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February 27, 1915, Vol LXIV, No. 9 >
ARTICLE | February 27, 1915

THE INFLUENCE OF CHANGES IN THE CHEMICAL ENVIRONMENT ON THE LIFE AND GROWTH OF TISSUES

LEO LOEB, M.D.
JAMA. 1915;LXIV(9):726-728. doi:10.1001/jama.1915.02570350020005.
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In addition to the method which, with a view of analyzing the effect of experimental variations in the physical and chemical environment on the life and growth of tissues, I published in 1897, and which permits study of the life and growth of tissues in the test-tube, outside the body,1 and with a later modification also inside the body — the latter serving as a living thermostat2 — there exists another method of studying the influence of apparently slight chemical changes on life and growth of tissues, namely, that of comparing the growth of tissues after transplantation into the same individual in which it originated (autotransplantation) and after transplantation into another individual of the same species (homoiotransplantation) and after transplantation into other species (heterotransplantation). In 19023 and again in 19074 I showed that tumors which die after homoiotransplantation live usually after autotransplantation. It may happen that

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