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JAMA. 1916;LXVII(9):662-666. doi:10.1001/jama.1916.02590090016005.
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Many bacteria retain for a long time the peculiar properties which determine their characteristic localization. The importance of studying the infecting power of some in which these properties are less fixed has not been sufficiently considered.

Some years ago I showed that the common occurrence of endocarditis in animals following intravenous injection of a staphylococcus from endocarditis and numerous strains of Streptococcus viridans from chronic infectious endocarditis depended to a certain extent on clump formation, and that simultaneously with the disappearance of this property, both from artificial cultivation and animal passage, endocarditis failed to develop.1

The importance of making injections soon after isolation of the bacteria was emphasized at that time. In 1909 Lewis and the writer2 reported the isolation of a diplococcus from the thrombus in the portal vein in primary portal thrombosis, which produced retrograde thrombosis in radicles of. the portal vein in a rabbit following


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