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S. P. BEEBE, Ph.D., M.D.
JAMA. 1915;LXIV(5):413-422. doi:10.1001/jama.1915.02570310033011.
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The physiologic and chemical studies of recent years have established the probability that the function of the thyroid gland is to prepare an active substance or hormone which is essential to the health of the organism. This substance probably is protein in character and contains iodin in chemical combination. This active substance probably forms a large portion of the colloid stored in the aveoli of the gland, and its physiologic activity is proportioned roughly to the iodin content. Under physiologic conditions only a sufficient amount of this hormone finds entrance to the circulation to meet the normal needs of the tissues, and recent work in this laboratory indicates that the control of this absorption is, at least in part, a function of the nervous system. When the gland for various reasons, which will not be discussed, becomes overactive, its secreting cells multiply, its circulation increases, the store of reserve material


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