Case I.—In the Spring of 1888, Mr. —, æt. 40, consulted me for great and constant pain in the left tibia. I found him in a hovel, poorly ventilated, poorly warmed, and poorly lighted. The odor in the room was simply unbearable, but with burning tar in the room I examined the patient as best I could. Found him greatly emaciated, with large ulcer on left leg, several inches in length, with the presence of pieces of dead bone. He was being cared for by some of the charitable ladies of the place and consented to an operation. Assisted by Drs. Thompson and Gebhart, I proceeded to operate. After the anæsthetic was given I washed and scrubbed his leg with soap and water, then with solution of bichloride of mercury, 1:1000; wrapped his feet with towels wrung out of the bichloride solution, and also covered his body with antiseptic