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Endocrinopathic Inheritance

Irving F. Stein, M.D.
JAMA. 1916;LXVI(23):1811. doi:10.1001/jama.1916.02580490059023.
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To the Editor:  —In an article on this subject (The Journal, May 6, 1916, p. 1438), Dr. Walter Timme analyzed a family history which apparently followed the mendelian laws of heredity. Timme concluded, on the basis of this analysis, that one may be able to forecast to some degree the characteristics of the offspring in certain marriages.I enclose a chart drawn similarly of a family originating in the union of a diabetic man (No. 1) and normal woman (No. 2). There were seven children in this family, three of whom (Nos. 4, 7 and 8) were diabetic. The oldest in this family (No. 3) married a man with a large simple goiter, and from this union eleven children were born, all apparently normal; the ages of these range from 18 to 40 years. Six of these were married and gave rise to twelve children with abnormality in only one—a


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