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JAMA. 1916;LXVI(23):1765-1768. doi:10.1001/jama.1916.02580490013005.
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This report is based on the investigation of changes in renal function produced by operations performed under general anesthesia, and of the variations in renal activity dependent on relief from back-pressure of urine. For this work, the rate of excretion of phenolsulphonephthalein and the concentration of urea in the blood have been taken as the indexes of renal activity. These tests were chosen because of their recognized value and because they are so easily performed. The phenolsulphonephthalein test was carried out by the technic of Rowntree and Geraghty.1 The determination of the urea concentration in the blood was made by the urease method introduced by Marshall.2 The concentration of total nonprotein nitrogen in the blood is probably a better index of renal efficiency, but the urea determination is made with less difficulty and can easily be made a routine clinical procedure. It is true that the proportion of


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