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THE TREATMENT OF ARTHRITIS BY THE INTRAVENOUS INJECTION OF FOREIGN PROTEIN

JOSEPH L. MILLER, M.D.; FRANK B. LUSK, M.D.
JAMA. 1916;LXVI(23):1756-1757. doi:10.1001/jama.1916.02580490004002.
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During the past year attention has been called to the value of intravenous typhoid vaccine in the treatment of typhoid fever. The early reports by Penna, Kraus and Mazza of Buenos Ayres, and the independent investigation by Ichikawa, demonstrated clearly that by this method of treatment a certain percentage of typhoids might be brought to an immediate termination. Kraus and somewhat later Lüdke were able to show that similar results could be obtained with a vaccine made from colon bacilli, this showing definitely that the reaction was not due to a specific vaccine. Lüdke later was able to show that a solution of albumose would accomplish the same results.1

During the past summer we used the intravenous typhoid vaccine, 200,000,000, in the treatment of typhoid. Later, following the suggestion of Lüdke, we thought it might be of interest to compare these results with a series treated with albumose. We

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