JAMA. 1914;LXIII(20):1766-1767. doi:10.1001/jama.1914.02570200060022.
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In view of the recent outbreak of foot-and-mouth disease in the Mississippi Valley, the most extensive as yet in the United States, a brief consideration of the principal features of the disease may be of interest. It is an acute, highly infectious disease, which occurs chiefly in cattle, sheep, goats and swine, though other animals such as the horse and dog, as well as certain wild animals are attacked also, and it may affect human beings. In animals it is characterized especially by the eruption of vesicles in the mouth and on the feet, in some species more in the mouth, in others more on the feet. In cattle the incubation period averages from three to five days, whereupon a moderate fever with loss of appetite and other general symptoms sets in. In two or three days small blisters appear on the lining of the mouth, and now the fever


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