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W. E. BURGE, Ph.D.; E. L. BURGE, A.M.
JAMA. 1916;LXVI(14):998-1000. doi:10.1001/jama.1916.02580400004002.
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A great many theories have been advanced concerning the cause of gastric ulcer. The main feature of most of these theories is that there is a decreased resistance of limited areas of the gastric wall followed by the digestion of these areas by the unrestricted action of the pepsin. The investigation reported in this paper is concerned with the cause of this diminished resistance. It has been recognized for a long time that the resistance to the action of the digestive juices of limited portions of the mucosa of the stomach is decreased by cutting off the blood supply to these portions as, for example, by a clot in a small blood vessel (thrombosis) or by the ligation of the vessel. Under such conditions the area is digested by the pepsin with the formation of an ulcer. The decreased resistance of the areas rendered anemic by cutting off the blood


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