JAMA. 1914;LXIII(10):870-871. doi:10.1001/jama.1914.02570100056020.
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Recently several serum tests for the diagnosis of carcinoma have been proposed. Among these may be mentioned Abderhalden's test for specific ferments for cancer-cells, Brieger and Trebing's antitrypsin reaction, the miostagmin reaction of Ascoli, Crile's isolysin reaction and von Dungern's complement-binding reaction. In the hands of careful workers experienced in the special technic, each of these methods seems to demonstrate a substance in the serum of cancer patients which reacts more or less specifically on a substance contained in cancer tissue; but none of the methods hitherto proposed has seemed by virtue of its reliability of result and simplicity of technic to merit general adoption as a diagnostic measure. This does not mean that such a method may not be found, or that further improvement in some of these methods may not make them suitable for general use.

Recently Kelling1 described a test which in the matter of simplicity


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