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JAMA. 1911;LVI(8):588-589. doi:10.1001/jama.1911.02560080036010.
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That mercury does not cure syphilis in all cases has been observed for many centuries. Christian Friedrich Harles1 mentions the fact that Fallopius and Libavius used arsenic in the treatment of syphilis. F. Hoffmann2 in the middle of the eighteenth century used the flores auri pigmenti diaphoretici, a sulphid of arsenic, satisfactorily in the treatment of "lues venerea inveterata," in cases in which mercury proved of no avail, and in cases in which ptyalism and mercurial poisoning were produced. Hoffmann asserts that he obtained excellent results by the internal administration of arsenic in the treatment of indolent syphilitic lymph-nodes, cachexia syphilitica, and in syphilitic periostitis. C. Ziegenbuehler3 used arsenic internally in the treatment of syphilitic arthritis with success. Horn4 and Renner5 treated old inveterate syphilitic lesions successfully with white arsenic. The use of arsenic in the treatment of syphilis is, therefore, by no means a


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