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JAMA. 1911;LVI(7):504-507. doi:10.1001/jama.1911.02560070036015.
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This group of cases includes chiefly those of dermatologic interest. At the time the work was done, the method of administration as recommended by most experimenters was by subcutaneous injection of an emulsion of the drug according to the Wechselmann method. After the first group of injections had been made subcutaneously in emulsion by this method, Dr. Flexner requested that the intramuscular method be employed, using a solution according to the method of Lesser. The second injection given in Case 7 and the one given in Case 8 were therefore made in this manner.

The cases included a well-defined macular, a papulopustular, a corymbose, a large flat papular, a deep gummatous (bones and deeper tissues) and an ordinary gummatous syphiloderm, and two in which early nervous lesions were exhibited. The patients were all examined for any contra-indications relative to heart, lungs, kidneys, etc., by Dr. Joseph L. Miller, and as


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