Warning as to Use of Hay-Fever Toxin

R. C. Lowdermilk, M.D.
JAMA. 1914;LXIII(6):502. doi:10.1001/jama.1914.02570060062025.
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To the Editor:  —Since the publication of my article on hay-fever in The Journal, July 11, 1914, p. 141, I have been receiving so many letters of inquiry that it is impossible to give each one a reply.I tried to make clear the fact that in its present form the method is not suited for general use. What I wrote was intended only for the laboratory worker with a thorough knowledge of the principles of immunity; such men can easily prepare their own toxin and vaccines and, after some study and experimentation, should be able to use the method successfully.All others should leave it alone. The toxin is as potent as tuberculin and requires fully as much judgment and care for its administration. I have seen some alarming reactions from it and am convinced that in some cases a dose sufficiently large would prove fatal. Any physician who,


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