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August 8, 1914, Vol LXIII, No. 6 >
ARTICLE | August 8, 1914

OBSERVATIONS ON THE PATHOLOGY OF SYPHILIS

HENRY J. NICHOLS, M.D.
JAMA. 1914;LXIII(6):466-468. doi:10.1001/jama.1914.02570060026007.
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It is hardly necessary to say that a knowledge of the real pathology of syphilis would be of great assistance in the practical handling of the disease. Our attempts to treat syphilitics would be more successful if we knew more about what is actually going on in the body, more about where and why the spirochetes localize and more about the mechanism of relapse. At present our knowledge on these and other points is in the making. What has passed for many years as the pathology of syphilis is really only a small part of the subject, namely, pathologic anatomy. This branch has been unusually barren of helpful suggestions, and such interpretations as have been made have necessarily not been convincing. It is only since the recent development of the pathologic physiology or experimental pathology of the subject that we are beginning really to understand something of the pathogenesis of

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AAM 2010;304:1493-1495.
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BMJ 2010;341:c5893-c1494.
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