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P. B. P.
JAMA. 1888;X(1):29-31. doi:10.1001/jama.1888.02400270045010.
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Pathology and Treatment of Diphtheria—Sarcoma in Bone.

At the last meeting of the County Medical Association Dr. J. Lewis Smith read a paper on Present Opinions Regarding the Pathology and Treatment of Diphtheria. He said that while the investigations concerning the etiology of the disease had clearly established its microbic origin, the microbe which was its specific principle had not been positively demonstrated; and he then went on to speak at some length of the bacillus observed by Loeffler and described by Klebs in 1883, cultures of which to the twenty-fifth generation, inoculated in guinea-pigs and birds, produced a whitish exudation at the point of inoculation. The investigations into the microbic origin of diphtheria lend considerable support to the theory that it is primarily a local disease, and that in certain mild cases it never becomes constitutional, or is constitutional only in a very feeble degree.


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