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The Culture of Cancer Cells in Vitro

Guido Volpino
JAMA. 1911;LVI(2):139. doi:10.1001/jama.1911.02560020055029.
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To the Editor:  —In The Journal (Oct. 15, 1910, p. 1379; Oct. 29, 1910, p. 1554, and later), Carrel and Burrows have published reports of very interesting experiments on the growth of normal and pathologic tissues outside of the body and on the culture of cells.I desire to inform the American medical public that on Dec. 10, 1909, I communicated to the Royal Medical Academy of Turin (Gior. d. r. Accad. di med. di Torino, 1909, No. 12) that I obtained in a semihardened horse-serum medium a development in vitro of mouse adenocarcinoma fragments. A second report on the same subject was made on March 11, 1910, and the results of several experiments were published in the Italian medical periodical Pathologica (Oct. 15, 1910). In the first communication I reported that small fragments of cancer placed in the serum had enlarged and changed their form after from ten to


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