JAMA. 1911;LVI(2):122-123. doi:10.1001/jama.1911.02560020038016.
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In the early days of the surgical pathology of the appendix the occurrence of neoplasms of this organ was not often noted, but as the laboratories of hospitals and clinics became better organized and thorough gross and microscopic examination of all surgical specimens became a matter of routine, a histologic diagnosis of cancer in an appendix removed for supposedly simple appendicitis began to be somewhat less of a rarity. The literature of this subject also began to increase rapidly, and although there were but a few scattered cases reported before 1900, since that time medical journals have teemed with reports of single cases or small groups of cases. In 1908 McWilliams1 was able to collect records of 105 cases, and since then a great number have been added, MacCarty2 having reported one group of twenty-two cases among five thousand appendices removed by the Mayos. Statistics from large clinics,


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