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The Propaganda for Reform

JAMA. 1912;LIX(22):1989-1990. doi:10.1001/jama.1912.04270110401020.
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Jordan, A.: Biochem. Jour. , 1911, v, 274.
Sollmann, T.: The Journal A. M. A. , (Sept. 5) , 1908, p. 818.
Burnam, C. F.: Arch. Int. Med. , (October) , 1912, p. 324.
The dependence of the concentration on the quantity of the urine is too often overlooked. It is probably as important as the dosage; 2 gm. per day, with the excretion of 2 liters of urine, has probably no more effect than 1 gm. when the urine excretion is 1 liter. Other secretions are not so much affected by the income of fluid, and for them the matter is of less importance.
Hald, P. F. Arch. f. exper. Path. u. Pharmakol. , 191, lxiv, 329.
Quoted from Jordan (see Note 1).
Crowe, S. J.: Arch. Internat, pharmacodyn. et thérap. , 1908, xviii, 315.
Crowe, S. J.: Bull. Johns Hopkins Hosp. , 1909, xx, 102.
This suggests that the administration of alkali (sodium acetate or citrate) would not interfere with the systemic action of hexamethylenamin, while it would tend to prevent the urinary irritation. Alkalies would of course be inadmissible if urinary antisepsis is desired.
Flexner and Clark: The Journal A. M. A. , (Feb. 25) , 1911, p. 585.

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