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THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

JAMA. 1912;LIX(19):1720-1725. doi:10.1001/jama.1912.04270110134024.
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[For other information see second page following reading matter]

SATURDAY, NOVEMBER 9, 1912 

THE ADRENALS AND THE SYMPATHETIC NERVOUS SYSTEM  There has arisen, of late, a growing appreciation of the fact that a considerable number of the physiologic responses of the organism may be under a sort of double control. On the one hand, impulses are brought to secretory cells or muscular structures along nervous paths; on the other, the humoral channels carry chemical compounds which may act directly on glandular or contractile mechanisms without any immediate intervention of the nervous system. In the case of respiration, for example, the carbon dioxid content of the circulating blood normally tends to regulate the character of the breathing movements. This is distinctly a type of chemical control in which the gaseous product of tissue waste acts

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