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ESSENTIAL, OR PRIMARY, LATERAL SCLEROSIS

JAMES HENDRIE LLOYD, M.D.; S. D. W. LUDLUM, M.D.
JAMA. 1912;LIX(13):1173-1177. doi:10.1001/jama.1912.04270090417011.
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CLINICAL REPORT BY DR. LLOYD  This subject, as I understand it, remains at the present time in much the same state as it was in nearly forty years ago. Even the definition of the term is not more precise; therefore, before the subject itself is discussed, this matter of definition should be considered.By primary lateral sclerosis, as the term is commonly used, seems to be meant a disease of the lateral, or motor, tracts, which is not the result of a secondary degeneration following on an initial lesion cutting off the degenerated tracts from the motor cortex of the brain. The process of wallerian degeneration in the motor tract is well known; it follows on a lesion cutting off the motor fibers from their cell bodies in the brain cortex; it is largely a downward degeneration, although not exclusively so, for upward degeneration is also noted. Such a lesion

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