JAMA. 1912;LIX(13):1160-1163. doi:10.1001/jama.1912.04270090404007.
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We are fortunately, now, in the midst of an age of careful analysis and investigation of all treatments of disease, and especially of drug treatments. We have passed through the era of absolute faith in drugs and combinations of drugs and mystical mixtures; we have passed through the era inaugurated by some of our best clinicians who were enthusiastic pathologists but therapeutic nihilists, and who spread the belief that drugs had no value; and we have come to the era of pharmacologic research and the knowledge derived from such investigations, which show that many drugs are potent and as such have valuable therapeuticuses.

We have not yet eliminated mystery from medical practice, and still have a belief (unless we very carefully eliminate it) in a multiple mixture, although it may not be a mysterious mixture- -we may know its contents. It is so easy to believe when we are told


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