JAMA. 1910;LIV(17):1357-1362. doi:10.1001/jama.1910.92550430001001c.
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The investigations of Pasteur1 proving that the disease of silkworms known as pebrine is due to infection by a living agent had the immediate practical result of restoring the languishing silk industry of France and Southern Europe, and also produced the greatest interest by the demonstration that disease can be produced in animals by infection with a microbe. The fact that the infectious agent is a protozoon received little attention, and for many years following Pasteur's discovery bacteria furnished the main object of medical investigation; only recently have numerous researches begun to reveal the frequency with which protozoa occur as parasites in man and the lower animals.

But if the expansion of the subject of parasitic protozoology is recent, the recognition of the tropical diseases, as a separate group, is even newer, and, in spite of the extremely rapid growth of our knowledge of these diseases, we must still regard


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