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April 16, 1910, Vol LIV, No. 16 >
ARTICLE | April 16, 1910

HEXAMETHYLENAMIN IN SUPPURATION OF THE MIDDLE EAR AND THE NASAL SINUSES

EDWARD J. BROWN, M.D.
JAMA. 1910;LIV(16):1308. doi:10.1001/jama.1910.92550420001001j.
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A case of acute suppuration of the middle ear treated by three daily doses of 5 grains of hexamethylenamin, with speedy recovery and the detection of the drug in the secretion of the ear, has recently been reported.1

A natural inference would be that the drug would be eliminated as well through the mucous membrane of the nasal sinuses, and the rapid improvement of two patients under the treatment suggested leads me to send this communication urging the trial of the remedy in both classes of cases.

Case 1.  —Miss L. B. G, aged 26, school teacher, consulted me March 7 for a stuffiness of the right ear which had lasted three days following a cold of two weeks. I found a subacute otitis media, the watch heard at half an inch and after slight inflation and use of the Siegle pneumatic otoscope, at 16 inches. The floor of the left naris was covered with mucopus flowing from the middle fossa. Transillumination showed

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