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THE OPSONIC INDEX OF BACILLUS-CARRIERS

ALICE HAMILTON, M.D.
JAMA. 1910;LIV(9):704-705. doi:10.1001/jama.1910.92550350001001m.
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The importance of the typhoid carrier as a conveyor of infection is being impressed on us daily, and we are greatly in need of some method for detecting such persons which is quicker and less cumbersome than the bacteriologic examination of stools and urine. Aside from the fact that the latter takes usually several days to carry out, there is the further disadvantage of intermittency in the excretion of typhoid and paratyphoid bacilli, which makes it possible for a carrier to escape detection for weeks or even months if the specimens are collected during one of the germ-free intervals. The agglutination test is positive in a certain proportion of carriers, but in the opsonic index we have apparently a means of diagnosis more rapid than the bacteriologic examination and more constant than the agglutination test. Gaehtgens1 recently examined the opsonic index of 12 typhoid convalescents who were

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