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ARTICLE |

THE CLINICAL ESTIMATION OF AMMONIA IN THE URINE BY THE FORMALIN METHOD

E. W. BROWN, M.D.
JAMA. 1909;LIII(25):2071-2073. doi:10.1001/jama.1909.92550250001001f.
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The great importance of the routine estimation of the urinary ammonia in cases of acidosis is now attracting much attention, and the object of this paper is to report the study of a method the technic of which is so simple as to be available to the average clinical worker with limited laboratory facilities. It is hoped that the more general adoption of the ammonia determination will thus be encouraged. Of the several forms of acidosis always tending to develop symptoms of acid intoxication, those which may occur in diabetes and pregnancy are probably' the most important. The chief urinary symptoms are: (1) the presence of the so-called acetone bodies, i. e., acetone, diacetic acid, and, in severe cases, beta-oxybutyric acid; (2) a marked increase in the relative and absolute output of ammonia. The quantitative determination of the acetone bodies, while highly desirable from the ' standpoints of both prognosis

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