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December 11, 1909, Vol LIII, No. 24 >
ARTICLE | December 11, 1909

THE DETERMINATION OF TRYPSIN IN THE STOMACH CONTENTS AFTER OIL TEST MEALS

CLIFFORD B. FARR, M.D.
JAMA. 1909;LIII(24):1964-1969. doi:10.1001/jama.1909.92550240001001d.
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ABSTRACT

The experiments reported in the following paper are based on the work of Boldireff and Volhard. The former in experiments on dogs found that the introduction of oil into the stomach caused regurgitation of duodenal contents, in which the presence of pancreatic ferments could be demonstrated; the latter devised a new method for demonstrating the presence of trypsin and applied Boldireff's discovery to clinical uses.

A. OBJECTS, METHOD AND RESULTS IN GIVING OIL TEST MEALS  My first object was to substantiate the observations of others as to the ease and frequency with which duodenal contents might be obtained after the oil meal.The second was to decide which of the methods proposed was best suited for detecting trypsin in the specimens secured.The third was to discover what, if any, clinical value was to be attached to the findings thus obtained.The oil meal as given, consisted of 100 to

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