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October 30, 1909, Vol LIII, No. 18 >
ARTICLE | October 30, 1909

Pharmacology

JAMA. 1909;LIII(18):1496-1499. doi:10.1001/jama.1909.02550180054010.
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1 +
The Journal A. M. A. , (Sept. 12) , 1908;, p. 931.
2 +
Mr. Teeple's letter and Prof. Orndorff's report appear on pages 8 and 10 respectively of the pamphlet; this pamphlet may be had on request.
3 +
The action of cellasin on a sugar solution is found to be slow at first. The examinations on which the first reports of the referee were based were made after an incubation for not more than 24 hours. The results were negative as to quantitative results. In the subsequent experiments a longer period of incubation gave considerable formation of acid. It is admitted by the manufacturers that the action of cellasin is too slow to be of use as an intestinal enzyme, but is claimed that it is an intracellular enzyme, similar to muscle enzymes, and acts after absorption into the blood. (As appears in Mr. Teeples' letter, page 8, and also report of Referee A, page 13 of the pamphlet.)
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Report of Referee A, page 13 of pamphlet.
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Report of Referee B, page 15 of pamphlet.
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In the earlier consideration of cellasin the Council having questioned the claim that cellasin was indestructible in 25 per cent. hydrochloric acid, Mead Johnson and Co. submitted. instead, the statement that cellasin is not destroyed by 2.5 per cent hydrochloric acid.

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