There has just been issued a bulletin entitled "Further Studies on the Phenomenon of Anaphylaxis,"1 which is the fourth bulletin issued by the Public Health and Marine-Hospital Service on this subject. It will be recalled that the first publication in English dealing with the phenomenon of anaphylaxis was issued by that service in 1906,2 and the above-mentioned bulletin is a continuation of these studies.
Rosenau and Anderson have devoted themselves largely to studies of the intimate nature of the factors that make up the phenomenon of anaphylaxis, subordinating for the time being the more or less unprofitable discussion of the theory of its mechanism. In their last publication they endeavored to determine what practical use there would be, in the prevention of anaphylaxis, in the administration of various hypnotics; and for this work they used urethane, paraldehyd, chloral and magnesium sulphate, but found that none of these substances