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ARTICLE |

Necrosis of the Liver After Chloroform Anesthesia

John R. Williams; W. D. Becker
JAMA. 1909;LII(24):1940. doi:10.1001/jama.1909.02540500042017.
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ABSTRACT

Dr. Krone's letter was submitted to Drs. Williams and Becker for comment, and they replied as follows:

To the Editor:  —Dr. Krone's criticism of our report is of interest because it suggests the widely different conclusions which careful students may arrive at from a given set of data. He states:In order to prove that chloroform in measured doses given to physiologic effect produces acute yellow atrophy of the liver, it will be necessary to collect cases in which the dosage has been accurate and the exclusion of pre-existing atrophy has been positive.It may be inferred from this that Dr. Krone believes it is not proven that chloroform has ever produced liver necrosis, but it seems to us that it has been too generally conceded and too well established to make this a point in a controversy. Moreover, the amount of chloroform administered apparently has little to do with

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