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April 3, 1909, Vol LII, No. 14 >
ARTICLE | April 3, 1909

COMPLEMENT FIXATION IN MALIGNANT DISEASE

CHARLES E. SIMON, M.D.
JAMA. 1909;LII(14):1090-1092. doi:10.1001/jama.1909.25420400016001e.
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In a recent paper published in conjunction with Dr. W. S. Thomas,1 I have pointed out that the blood serum of cancer patients may contain a substance or substances which, in the presence of cancer extract, will bind a larger amount of complement than the blood serum of normal individuals. It was found that this reaction could be obtained in about 65 per cent, of the cancer cases, while it was absent in 98 per cent, of our non-cancerous patients and in all normal persons. The small number of positive results in non-malignant cases finds its probable explanation in the fact that cancer antigen may react with the blood serum of syphilitic individuals and thus likewise bring about an abnormal degree of complement fixation. Our paper was sent to the Journal of Experimental Medicine early in May, and we were hence unable to notice certain papers bearing on the

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