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CONGENITAL FAMILY CHOLEMIA

JAMA. 1909;LII(10):776. doi:10.1001/jama.1909.02540360032006.
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One of the most fascinating features of the study of medicine is the constantly occurring changes. New signs are continually being described, and new diseases are constantly being split off from groups which appeared in the not distant past to be reduced to their final segregates. Among these relatively new conditions is one so far but little noted in this country, the disease known as congenital family cholemia or acholuric jaundice. Isolated instances and small groups of cases have been described for years, and recently Hawkins and Dudgeon1 have collected most of these, and have added some carefully studied cases of their own. It is probable that, like other apparently rare diseases, the condition will be found to be more common when more widely known.

The main characteristics of this curious affection are indicated in its name; it tends to affect several members of a family, it is usually

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