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ENTEROGENOUS CYANOSIS

JAMA. 1909;LII(7):565. doi:10.1001/jama.1909.02540330047009.
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Enterogenous cyanosis was first described by Stokvis-of Rotterdam in 1902. The case he reported was that of a soldier who had cyanosis of four years' duration associated with chronic diarrhea. On spectroscopic examination of the patient's blood Stokvis recognized the spectrum of methemoglobin and attributed the cyanosis to the presence of this substance in the blood. In the same year Talma of Utrecht showed that the methemoglobin of enterogenous cyanosis was intracorpuscular, as distinguished from that of drug poisoning in which the methemoglobin may be found in the blood plasma. Three years later van der Bergh distinguished, for the first time, between enterogenous cyanosis due to methemoglobin and that due to sulph-hemoglobin. Solutions of sulph-hemoglobin and methemoglobin both show spectroscopically an absorption band in the red. The two bands, however, are in different positions and that of methemoglobin disappears on the addition of ammonium sulphid to the solution, while the

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