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February 13, 1909, Vol LII, No. 7 >
ARTICLE | February 13, 1909

HEART HYPERTROPHY AND NEPHRITIS

JAMA. 1909;LII(7):565. doi:10.1001/jama.1909.02540330047008.
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Heart hypertrophy in nephritis seems always to offer problems that defy the pathologist, in spite of the abundant material that is always at hand for his study. Not only do we lack definite knowledge of the cause of the increased blood pressure which leads to the hypertrophy, but we have no consistent data as to just what sort of anatomic changes must be present in the kidney in order that heart hypertrophy may result. While the classical text-book dogma that parenchymatous nephritis leads to edema without heart hypertrophy and that interstitial nephritis leads to hypertrophy with little or no edema is correct in a considerable proportion of cases, yet the exceptions are so abundant as to make the rule of little value in explaining the relation of renal changes to heart hypertrophy. Hypertrophy accompanying typical parenchymatous nephritis is by no means rare, while even more common is the occurrence of

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