It is probably a unique circumstance in the history of pathology that a complex of symptoms so striking as hemoglobinuric fever should have such an obscure history. As this obscurity is intimately associated with the etiology and symptomatology of the condition an investigation of some of the factors in its history is not without interest. After a short statement of the history of hemoglobinuric fever I shall breifly consider how far it has been influenced by, first, its confusion with bilious remittent fever and yellow fever; second, the introduction of cinchona bark and its alkaloids into the treatment of malaria, and, third, the advent of Europeans into regions where the fever is endemic.
HISTORY OF HEMOGLOBINURIC FEVER
In the years from 1850 to 1853 blackwater fever was described by Lebeau, Daullé and Leroy de Méricourt, physicians of the French navy, who observed it in Madagascar and, especially, on the island