As one of the earlier investigators of lesions of the vascular system occurring in the rabbit after intravenous injections of adrenalin1 I have been interested in the observation of Drs. Miles and Johnstone2 concerning the frequent occurrence of spontaneous arterial lesions. These investigators suggest that the vascular lesions, ascribed by many observers to the injection of adrenalin, are in reality of spontaneous origin. In support of this view they present the results of the examination of a large number of normal rabbits in which lesions similar to those produced by adrenalin occurred with equal or greater frequency.
The inevitable conclusion is either that the spontaneous lesions are common and that the individuals working with adrenalin have been careless about their controls, or that rabbits of certain localities, or those raised or kept under certain conditions, are peculiarly prone to spontaneous lesions. The first of these conclusions has been