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Pharmacology

JAMA. 1908;LI(9):773-774. doi:10.1001/jama.1908.02540090055012.
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Horton (Ber. d. deut. Chem. Ges. , xxi, p. 2000)
P. Dobriner (Zeit. f. anal. Chem. , xxxvi, p. 44)
white body which later turned to a mass of crystals. This crystalline body when washed and dried and boiled with dilute acid liberated formaldehyd. The resulting solution responded to tests for ammonia, hexamethylenamin and mercury. The same test applied to pure hexamethylenamin solution gave exactly the same results. A still further confirmation that hexamethylenamin was present as such and not in some combination which bromin water or mercuric chlorid might decompose, was the fact that chloroform extracted from Uriseptin a substance that had the same crystalline form as pure hexamethylenamin crystallized from chloroform, and which responded to all the above reactions for hexamethylenamin.
Quantitative Test for Hexamethylenamin.—Uriseptin was boiled with alkali to liberate and drive off all ammonia present as ammonium compounds, and then boiled with acid to decompose the hexamethylenamin. Finally the mixture was made alkaline again to liberate the ammonia resulting from the decomposition of the hexamethylenamin and distilled into normal acid; the actual quantities taken and the results obtained are given here: It was found that 5.0346 gm. of Uriseptin yielded an equivalent of 74.43 c.c. tenth-normal ammonia and 5.0197 gm. Uriseptin yielded an equivalent of 74.33 c.c. tenth-normal ammonia. The average of the two calculated to hexamethylenamin gives the result given above, 5.51 gm. per 100 c.c. or 25.15 grains hexamethylenamin per fluidounce.
Lithium.—This element was identified in the ash resulting from the incineration of Uriseptin by the ordinary tests.
Benzoic Acid.—This was found by making a chloroform extraction of an acid solution of Uriseptin and applying tests for benzoic acid to the residue left after the evaporation of the chloroform.
Gooch (Amer. Chem. Jour. , ix, p. 33).
 Iodofan , The Journal A. M. A. , (March 7) , 1908, 784
 Arhovin , The Journal A. M. A. , (May 9) , 1908, 1541.
Apotheker Zeitung , (July 18) , 1908, p. 521.
Apotheker Zeitung , (July 22) , 1908, p. 529.
Apotheker Zeitung , (July 25) , 1908, p. 538.

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