JAMA. 1908;L(24):1982-1984. doi:10.1001/jama.1908.25310500030002f.
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At a meeting of the Berlin Medical Society, May 8, 1907, von Pirquet1 described his method of vaccinating, using a preparation of tuberculin, and reported 360 cases, all children, in which it had been tried. Of these clinically diagnosed "tuberculosis" a positive result was obtained in 88 per cent. The negative 12 per cent. occurred in the miliary cases or in those patients with cachexia, while 167 of the "unsuspected" gave positive results. In the discussion Wolff-Eisner1 called attention to the possibility of obtaining a reaction to tuberculin when applied locally to other parts of the body and reported having observed such when a 1 to 10 dilution was used in the eye of a hay fever patient. This he had observed frequently and he described the reaction as consisting of a conjunctivitis, a chemosis, while in some cases the patient presented the condition observed in a general reaction


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