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COMPARATIVE POTENCY OF HYOSCIN AND SCOPOLAMIN HYDROBROMID IN REFRACTION WORK.

WENDELL REBER, M.D.
JAMA. 1908;L(17):1323-1327. doi:10.1001/jama.1908.25310430007001a.
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Some years age in some notes1 on the mydriatic alkaloids I made mention of a youth of 16 with emmetropic eyes on whom I had tested the effects of hyoscin hydrobromid and scopolamin hydrobromid. One drop of a 1/10 per cent, solution of the hyoscin salt was used in the right eye and one drop of a 1/10 per cent, solution of the scopolamin salt was used in the left eye. The effect of the two drugs on the pupil is shown in Figure 1 and on the ciliary muscle in Figure 2. From these results I leaned to the conclusion that the two drugs were practically identical in action and, therefore, interchangeable, and I so put myself on record at that time. For some time afterward I ordered 1/10 per cent, of solutions of scopolamin or hyoscin hydrobromid indiscriminately in my office refraction work, but it was not

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