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JAMA. 1887;IX(11):336-338. doi:10.1001/jama.1887.02400100016003.
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Diagnosis of Sarcoma of the Breast.  —In an article on "Sarcoma of the Female Breast," Dr. S. W. Gross says:Between the spindle-celled, round-celled, and giant-celled there are marked similarities which render their differentiation difficult. The spindle-celled, however, are characterized by their development at a comparatively early age; by the attendant suffering; by the enlargement of the subcutaneous veins; by their slow reproduction after removal; and by their long life. The round-celled, on the other hand, appear, as a rule, at a comparatively late age, and are painless; but the skin is liable to be discolored and ulcerated, and recurrence is rapid, and the duration of life is relatively short. The giant-celled likewise appear late in life, but are painful; discoloration of the skin and ulceration are also common; but there is no enlargement of the veins, while irritative enlargement of the axillary glands is frequent. Local reproduction is delayed


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