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Effect of CCR2 and CCR5 Variants on HIV Disease Abstract and Commentary

Ronald G. Collman, MD
JAMA. 1997;278(23):2113-2114. doi:10.1001/jama.1997.03550230089046.
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Clapham PR.  HIV and chemokines: ligands sharing cell-surface receptors . Trends Cell Biol . 1997;7:264-268.
Link to Article[[XSLOpenURL/10.1016/S0962-8924(97)01075-1]]
Zhu T, Mo H, Wang N, et al.  Genotypic and phenotypic characterization of HIV-1 in patients with primary infection . Science . 1993;261:1179-1181.
Link to Article[[XSLOpenURL/10.1126/science.8356453]]
Schuitemaker H, Koot M, Kootstra NA, et al.  Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus populations . J Virol . 1992;66:1354-1360.
Liu R, Paxton WA, Choe S, et al.  Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection . Cell . 1996;86:367-377.
Link to Article[[XSLOpenURL/10.1016/S0092-8674(00)80110-5]]
Samson M, Libert F, Doranz BJ, et al.  Resistance to HIV-1 infection of Caucasian individuals bearing mutant alleles of the CCR5 chemokine receptor gene . Nature . 1996;382:722-725.
Link to Article[[XSLOpenURL/10.1038/382722a0]]
Dean M, Carrington M, Winkler C, et al.  Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CCR5 structural gene . Science . 1996;273:1856-1862.
Link to Article[[XSLOpenURL/10.1126/science.273.5283.1856]]
Biti R, French R, Young J, Bennetts B, Stewart G.  HIV-1 infection in an individual homozygous for the CCR5 deletion allele . Nature Med . 1997;3:252-253.
Link to Article[[XSLOpenURL/10.1038/nm0397-252]]
Michael NL, Chang G, Louie LG, et al.  The role of viral phenotype and CCR5 gene defects in HIV-1 transmission and disease progression . Nature Med . 1997; 3:338-340.
Link to Article[[XSLOpenURL/10.1038/nm0397-338]]
Connor RI, Sheridan KE, Ceradini D, Choe S, Landau NR.  Change in coreceptor use correlates with disease progression in HIV-1-infected individuals . J Exp Med . 1997;185:621-628.
Link to Article[[XSLOpenURL/10.1084/jem.185.4.621]]
He JL, Chen YZ, Farzan M, et al.  CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia . Nature . 1997;385:645-649.
Link to Article[[XSLOpenURL/10.1038/385645a0]]
Doranz BJ, Rucker J, Yi Y, et al.  A dual-tropic HIV-1 isolate that uses fusinand the b-chemokine receptors CKR-5, CKR-3 and CKR-2b as fusion cofactors . Cell . 1996;85:1149-1158.
Link to Article[[XSLOpenURL/10.1016/S0092-8674(00)81314-8]]
Smith MW, Dean M, Carrington M, et al.  Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression . Science . 1997;277:959-965.
Link to Article[[XSLOpenURL/10.1126/science.277.5328.959]]
Michael NL, Louis LG, Rohrbaugh AL, et al.  The role of CCR5 and CCR2 polymorphisms in HIV-1 transmission and disease progression . Nature Med . 1997;3:1160-1162.
Link to Article[[XSLOpenURL/10.1038/nm1097-1160]]
Smith MW, Carrington M, Winkler C, et al.  CCR2 chemokine receptor and AIDS progression . Nature Med . 1997;3:1052-1053.


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