Losartan-Induced Hepatotoxicity

Xavier Bosch, MD, PhD
JAMA. 1997;278(19):1572. doi:10.1001/jama.1997.03550190036037.
Text Size: A A A
Published online

To the Editor.  —Losartan is an orally active, nonpeptide angiotensin II type I receptor antagonist that has been licensed for the treatment of hypertension in many countries. This new drug also produces beneficial hemodynamic effects both acutely and with long-term dosing in patients with symptomatic heart failure.1 Adverse events related to losartan are uncommon and mainly include headache, hypotension, renal dysfunction, and hyperkalemia.1-3 Herein we describe a patient who developed acute severe hepatic injury while taking losartan.

Report of a Case.  —A 46-year-old man was admitted in September 1996 because of a 2-week history of malaise, anorexia, nausea, vomiting, low-grade fever, and jaundice. He had been well until 3 months before admission when treatment with enalapril, 10 mg/d, was prescribed for moderate essential hypertension. One month before admission, treatment with enalapril was stopped because of persistent cough attributed to this drug, and losartan, 50 mg/d, was given instead.


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.