We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Death From Irreversible Pulmonary Hypertension Associated With Short-term Use of Fenfluramine and Phentermine

Kelley A. Dillon, RPh; Kathleen G. Putnam, RPh; Jerry L. Avorn, MD
JAMA. 1997;278(16):1320. doi:10.1001/jama.1997.03550160040035.
Text Size: A A A
Published online


To the Editor.  —Drug-induced pulmonary hypertension is a potentially dangerous adverse effect of anorexiant drugs. Reports of severe adverse effects, including fatalities, are increasing with the rising use of these medications. Data are sparse on the relationship between risk of pulmonary hypertension and duration of use of these agents. Abenhaim et al1 detected a markedly increased risk (odds ratio [OR], 23.1; 95% confidence interval [CI], 6.9-77.7) with exposure of more than 3 months but a nonsignificant risk (OR, 1.8; 95% CI, 0.5-5.7) for exposure of 3 months or less.1 Likewise, little is known about the fatality rate of anorexiant-induced pulmonary hypertension and what predisposing conditions might increase this risk. We describe a case that highlights the critical nature of these questions.

Report of a Case.  —A 30-year-old woman was in apparently good health until April 1996, when she was prescribed fenfluramine hydrochloride and phentermine hydrochloride for weight loss


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.