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ARTICLE |

Patterns of Tuberculosis Transmission in Central Los Angeles

Peter F. Barnes, MD; Zhenhua Yang, PhD; Susan Preston-Martin, PhD; Janice M. Pogoda, PhD; Brenda E. Jones, MD; Michiko Otaya, BSN; Kathleen D. Eisenach, PhD; Laura Knowles, MSPH; Sydney Harvey, PhD; M. Donald Cave, PhD
JAMA. 1997;278(14):1159-1163. doi:10.1001/jama.1997.03550140051039.
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Context.  —Recent studies suggest that many tuberculosis cases in urban areas result from recent transmission. Delineation of the epidemiologic links between patients is important to optimize strategies to reduce tuberculosis transmission.

Objective.  —To identify epidemiologic links among recently infected urban patients with tuberculosis.

Design.  —Prospective evaluation of patients with tuberculosis.

Setting.  —Central Los Angeles, Calif.

Patients.  —A total of 162 patients who had culture-proven tuberculosis.

Interventions.  —Patients were prospectively interviewed to identify their contacts and whereabouts. The IS6110-based and pTBN12-based restriction fragment length polymorphism analyses were performed on Mycobacterium tuberculosis isolates. Patients whose isolates had identical or closely related restriction fragment length polymorphism patterns were considered a cluster. Unconditional logistic regression was used to identify independent predictors of clustering.

Main Outcome Measures.  —Relationship of clinical and epidemiologic variables to clustering.

Results.  —A total of 96 (59%) of 162 patients were in 8 clusters. Only 2 of the 96 clustered patients named others in the cluster as contacts. The degree of homelessness was an independent predictor of clustering. Compared with non-clustered patients, patients in 6 clusters were significantly more likely to have spent time at 3 shelters and other locations when at least 1 patient in the cluster was contagious, and these locations were independent predictors of clustering. Among nonhomeless persons, clustered patients were significantly more likely than non-clustered patients to have used daytime services at 3 shelters.

Conclusions.  —(1) Traditional contact investigation does not reliably identify patients infected with the same M tuberculosis strain, and (2) locations at which the homeless congregate are important sites of tuberculosis transmission for homeless and nonhomeless persons. Measures that reduce tuberculosis transmission should be based on locations rather than on personal contacts.

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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