0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Contempo 1997: Family Medicine-Reply

David Nicklin, MD; Marjorie A. Bowman, MD, MPA
JAMA. 1997;278(14):1151-1152. doi:10.1001/jama.1997.03550140043035.
Text Size: A A A
Published online

In Reply.  —We agree with Dr Solan that evidence for the efficacy of vitamin E in the prevention of coronary artery disease is less compelling than that for antiplatelet agents and estrogen in women. However, there is considerable evidence of benefit. Large prospective epidemiological cohort studies have shown strong associations between vitamin E use and decreased risk of cardiovascular events. Four populationbased studies involving more than 172 000 men and women show remarkable agreement, with high vitamin E intake being associated with a consistent reduction in risk of cardiovascular morbidity and mortality of between 36% and 58%.1-2Randomized controlled trials, primarily of secondary prevention, have yielded less impressive results. A large randomized controlled trial of large doses of natural (not synthetic) vitamin E in smokers and nonsmokers with proven coronary artery disease showed a risk reduction for nonfatal myocardial infarction and cardiovascular death of 47% in the vitamin E group, but

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();