We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Clinical Crossroads: A 21-Year-Old Woman With Menstrual Irregularity

John T. Littell, MD
JAMA. 1997;278(10):822. doi:10.1001/jama.1997.03550100048036.
Text Size: A A A
Published online


To the Editor.  —With regard to the case of the 21-year-old woman with menstrual irregularity,1 I would like to point out that this patient's menstrual irregularities commenced within 6 months of discontinuing (what appeared to be) depomedroxyprogesterone acetate injections (after only 2 injections). Dr Davis correctly states that "duration of use [of depomedroxyprogesterone] does not correlate with the duration of ovulatory suppression."In my practice of family medicine, I have seen many young women who have experienced dramatic changes in their menstrual pattern with depomedroxyprogesterone, often after receiving but a single injection. Yet none of these women (in my experience) was counseled beforehand about this relatively frequent adverse effect as well as many other unpleasant adverse effects of depomedroxyprogesterone, including depression, weight gain, and osteoporosis.Hopefully, the objective presentation of case studies and clinical research dealing with the untoward effects of depomedroxyprogesterone will help those caring for patients seeking contraceptive advice to achieve


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.