"I will always remember four days in my life: the birth of each of my children, the day President Kennedy was shot, and the day my younger son was diagnosed with leukemia. That day will always be frozen in my mind." So goes a line from my favorite chapter in Principles and Practice of Pediatric Oncology. Indeed, few things in life are as devastating to a family as the diagnosis of cancer in a beloved child. Yet, in the midst of this devastation springs hope, and justifiably so, for the development of effective treatment for pediatric malignancies ranks as one of the major achievements of 20th-century medicine. Modern treatment of children with cancer is complex and requires a multidisciplinary approach, generally in the setting of a major medical center participating in national clinical research trials.
In this third edition, Pizzo and Poplack, along with 133 contributors, have attempted to address