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ARTICLE |

Vitamin E Supplementation and In Vivo Immune Response in Healthy Elderly Subjects:  A Randomized Controlled Trial

Simin Nikbin Meydani, DVM, PhD; Mohsen Meydani, DVM, PhD; Jeffrey B. Blumberg, PhD; Lynette S. Leka; George Siber, MD; Robert Loszewski; Claudette Thompson; Marcos C. Pedrosa, MD; Richard D. Diamond, MD; B. David Stollar, MD
JAMA. 1997;277(17):1380-1386. doi:10.1001/jama.1997.03540410058031.
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Objective.  —To determine whether long-term supplementation with vitamin E enhances in vivo, clinically relevant measures of cell-mediated immunity in healthy elderly subjects.

Design.  —Randomized, double-blind, placebo-controlled intervention study.

Setting and Participants.  —A total of 88 free-living, healthy subjects at least 65 years of age.

Intervention.  —Subjects were randomly assigned to a placebo group or to groups consuming 60, 200, or 800 mg/d of vitamin E for 235 days.

Main Outcome Measures.  —Delayed-type hypersensitivity skin response (DTH); antibody response to hepatitis B, tetanus and diphtheria, and pneumococcal vaccines; and autoantibodies to DNA and thyroglobulin were assessed before and after supplementation.

Results.  —Supplementation with vitamin E for 4 months improved certain clinically relevant indexes of cell-mediated immunity in healthy elderly. Subjects consuming 200 mg/d of vitamin E had a 65% increase in DTH and a 6-fold increase in antibody titer to hepatitis B compared with placebo (17% and 3-fold, respectively), 60-mg/d (41% and 3-fold, respectively), and 800-mg/d (49% and 2.5-fold, respectively) groups. The 200-mg/d group also had a significant increase in antibody titer to tetanus vaccine. Subjects in the upper tertile of serum α-tocopherol (vitamin E) concentration (>48.4 μmol/L [2.08 mg/dL]) after supplementation had higher antibody response to hepatitis B and DTH. Vitamin E supplementation had no effect on antibody titer to diphtheria and did not affect immunoglobulin levels or levels of T and B cells. No significant effect of vitamin E supplementation on autoantibody levels was observed.

Conclusions.  —Our results indicate that a level of vitamin E greater than currently recommended enhances certain clinically relevant in vivo indexes of T-cell-mediated function in healthy elderly persons. No adverse effects were observed with vitamin E supplementation.

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