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Relationship Between HLA-C Locus and Restenosis After Coronary Artery Balloon Angioplasty

Yoshiro Watanabe, MD; Nobuhiro Yamada, MD, PhD; Hisashi Yokoi, MD; Yasumasa Fujiwara, MD; Hiroshi Mokuno, MD; Hiroyuki Daida, MD; Hiroshi Yamaguchi, MD
JAMA. 1997;277(12):983-984. doi:10.1001/jama.1997.03540360051030.
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Objectives.  —To determine the relationship between human leukocyte antigen (HLA) loci and restenosis after percutaneous transluminal coronary angioplasty (PTCA).

Design and Setting.  —Cross-sectional study in patients treated by PTCA at Juntendo University Hospital, Tokyo, Japan.

Patients.  —A total of 65 patients (58 males and 7 females) with coronary artery stenosis who were consecutively selected between October 1994 and June 1995.

Main Outcome Measures.  —Significant relationships between the restenosis and the HLA-Cw1

Results.  —Among HLA-C locus, Cw1 was negatively related to restenosis (multivariate adjusted odds ratio, 0.19; 95% confidence interval, 0.06-0.63; P=.007).

Conclusions.  —In HLA typing, Cw1 may be a useful marker for the prediction of restenosis after PTCA.


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