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Intracytoplasmic Sperm Injection and Potential Transmission of Genetic Disease

Benjamin M. Tripp, MD; Thomas F. Kolon, MD; Collin Bishop, PhD; Larry I. Lipshultz, MD; Dolores J. Lamb, PhD
JAMA. 1997;277(12):963-964. doi:10.1001/jama.1997.03540360031020.
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To the Editor.  —Dr Palermo and colleagues1 recently reported that when intracytoplasmic sperm injection (ICSI) was used to produce pregnancy, the pregnancies, frequency of chromosomal abnormalities, and incidence of congenital abnormalities in the babies conceived in such a manner were comparable to those conceived with standard in vitro fertilization (IVF).Although this study is reassuring, its conclusions may lead to the injudicious, and sometimes inappropriate, use of ICSI and similar technology, ie, round spermatid nuclear injection. With the advent of ICSI combined with testicular sperm extraction as a therapeutic option, men with clinical azoospermia, who were once thought to be sterile and untreatable, now have the ability to procreate.A major concern with ICSI is the potential transmission of genetic disease to offspring.2 A host of known genetic diseases and syndromes can cause male infertility, and more are yet to be delineated. With the use of ICSI, these

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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