March 26, 1997, Vol 277, No. 12 >

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ARTICLE | March 26, 1997

BRCA1 Mutations in Women With Ovarian Cancer-Reply

Baruch Modan, MD, DrPH; Eitan Friedman, MD, PhD; Galit Hirsh-Yechezkel, MSc

JAMA. 1997;277(12):963. doi:10.1001/jama.1997.03540360031019.

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In Reply. —Our preliminary data related to the frequency of the 185delAG germline mutation in the BRCA1 gene in a subset of 79 of 585 Israeli women with ovarian cancer. Our study included 16 patients (20.3%) with borderline histopathology, none of whom carried the mutation. In subsequent extended analysis, 2 (5.6%) of 36 additional borderline cases were found to be mutation carriers (unpublished data). The latter finding is in line with the findings of 2.9% of mutation carriers having a positive family history among women with low malignant potential ovarian cancer (ie, presumably borderline) reported by Dr Shushan et al.¹ Similarly, Rubin and coworkers² reported that of 53 patients with ovarian cancer who might have been carriers of a variety of BRCA1 mutations, 3 were of a low malignant potential type.These data indeed support the notion that the genetics of borderline ovarian tumors differ from that of the invasive

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Modan B, Friedman E, Hirsh-Yechezkel G. BRCA1 Mutations in Women With Ovarian Cancer-Reply. JAMA. 1997;277(12):963. doi:10.1001/jama.1997.03540360031019.

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